Determinants of Malignant Transformation in Fibrocystic Disease of Breast
نویسنده
چکیده
Background: Fibrocystic disease of the breast in one of the commonest diseases in women above 30 years of age. The assumption of it being innocuous and benign is questionable with increased incidence of malignancies developing in these women. Introduction: Understanding the pathophysiology of fibrocystic disease is essential for identifying determinants of malignant change. Case Report: A case of carcinoma of breast developing in a longstanding and recurrent fibrocystic disease is reported. Discussion: The pathological changes including the influence of hormones on the natural history of the disease are discussed to identify the determinants of malignant transformation. Conclusion: Breast cyst fluid, patterns of cellular lining of the cysts, multiplicity, recurrence and patterns of cellular morphology are important determinants of malignant change.
منابع مشابه
بررسی شیوع تغییرات فیبروکیستیک در نمونههای ماموپلاستی ارجاع شده به بخش آسیبشناسی بیمارستان حضرت فاطمه از سال 1373 لغایت 1381
Fibrocystic changes represent the most common disorder of the breast which its prevalence is reported up to 59% in journals. Hormonal imbalance is considered to be basic to the development of this disorder and is diagnosed frequently between the age of 20 to 40 years. The most clinical presentings are palpable mass or mammographic densities and calcifications or nipple discharge. In mor...
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